Overview

  • Product nameAnti-ALDH5A1 antibody
    See all ALDH5A1 primary antibodies
  • Description
    Mouse polyclonal to ALDH5A1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human ALDH5A1 protein (NP_001071.1).

  • Positive control
    • Human liver tissue lysate, K562 cell lysate and ALDH5A1 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab89627 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 57 kDa.

Target

  • FunctionCatalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
  • Tissue specificityBrain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta.
  • PathwayAmino-acid degradation; 4-aminobutanoate degradation.
  • Involvement in diseaseDefects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) [MIM:271980]. SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development.
  • Sequence similaritiesBelongs to the aldehyde dehydrogenase family.
  • Cellular localizationMitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • Aldedehyde dehydrogenase 5 family antibody
    • Aldehyde dehydrogenase 5 family member A1 antibody
    • Aldehyde dehydrogenase 5A1 antibody
    • Aldehyde dehydrogenase family 5 member A1 antibody
    • ALDH5A 1 antibody
    • Aldh5a1 antibody
    • mitochondrial antibody
    • Mitochondrial succinate semialdehyde dehydrogenase antibody
    • NAD(+) dependent succinic semialdehyde dehydrogenase antibody
    • NAD(+)-dependent succinic semialdehyde dehydrogenase antibody
    • SSADH antibody
    • SSDH antibody
    • SSDH_HUMAN antibody
    • Succinate semialdehyde dehydrogenase antibody
    • Succinate-semialdehyde dehydrogenase antibody
    see all

Anti-ALDH5A1 antibody images

  • Anti-ALDH5A1 antibody (ab89627) at 1 µg/ml + human Liver tissue lysate at 50 µg

    Predicted band size : 57 kDa
    Observed band size : ~57 kDa (why is the actual band size different from the predicted?)
  • Anti-ALDH5A1 antibody (ab89627) at 1 µg/ml + K-562 cell lysate at 50 µg

    Predicted band size : 57 kDa
    Observed band size : 57 kDa
    Additional bands at : 35 kDa. We are unsure as to the identity of these extra bands.
  • All lanes : Anti-ALDH5A1 antibody (ab89627) at 1 µg/ml

    Lane 1 : ALDH5A1 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 57 kDa
    Observed band size : 57 kDa

References for Anti-ALDH5A1 antibody (ab89627)

ab89627 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab89627.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"