Overview

  • Product name
  • Description
    Rabbit polyclonal to ALG1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to a region within amino acids 59-350 of Human ALG1 (Uniprot ID: Q9BT22).

  • Positive control
    • 293T, A431, H1299 and Raji whole cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab154737 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 53 kDa.

Target

  • Function
    Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.
  • Pathway
    Protein modification; protein glycosylation.
  • Involvement in disease
    Defects in ALG1 are the cause of congenital disorder of glycosylation type 1K (CDG1K) [MIM:608540]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
  • Sequence similarities
    Belongs to the glycosyltransferase 1 family.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4-mannosyltransferase antibody
    • Alg1 antibody
    • ALG1_HUMAN antibody
    • asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase) antibody
    • asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae) antibody
    • Asparagine-linked glycosylation protein 1 homolog antibody
    • Beta 1 4 mannosyltransferase antibody
    • Beta-1 antibody
    • CDG1K antibody
    • Chitobiosyldiphosphodolichol beta-mannosyltransferase antibody
    • GDP Man GlcNAc2 PP dolichol mannosyltransferase antibody
    • GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase antibody
    • GDP-mannose-dolichol diphosphochitobiose mannosyltransferase antibody
    • Hmat-1 antibody
    • HMAT1 antibody
    • HMT 1 antibody
    • HMT1 antibody
    • Mannosyltransferase 1 antibody
    • Mannosyltransferase-1 antibody
    • MT 1 antibody
    • MT-1 antibody
    • MT1 antibody
    see all

Images

  • Anti-ALG1 antibody (ab154737) at 1/500 dilution + 293T whole cell lysate at 30 µg

    Predicted band size : 53 kDa

References

ab154737 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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