Overview

  • Product name
  • Description
    Rabbit polyclonal to ALG1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Caenorhabditis elegans
  • Immunogen

    Synthetic peptide corresponding to Caenorhabditis elegans ALG1 aa 76-97.
    Sequence:

    DLEEIPNSPPTQPQTFSDVPQR

  • Positive control
    • Wild type Caenorhabditis elegans extract.

Properties

Applications

Our Abpromise guarantee covers the use of ab155935 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/5000. Predicted molecular weight: 112 kDa.

Target

  • Function
    Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.
  • Pathway
    Protein modification; protein glycosylation.
  • Involvement in disease
    Defects in ALG1 are the cause of congenital disorder of glycosylation type 1K (CDG1K) [MIM:608540]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
  • Sequence similarities
    Belongs to the glycosyltransferase 1 family.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Alternative names
    • 4-mannosyltransferase antibody
    • Alg1 antibody
    • ALG1_HUMAN antibody
    • asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase) antibody
    • asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae) antibody
    • Asparagine-linked glycosylation protein 1 homolog antibody
    • Beta 1 4 mannosyltransferase antibody
    • Beta-1 antibody
    • CDG1K antibody
    • Chitobiosyldiphosphodolichol beta-mannosyltransferase antibody
    • GDP Man GlcNAc2 PP dolichol mannosyltransferase antibody
    • GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase antibody
    • GDP-mannose-dolichol diphosphochitobiose mannosyltransferase antibody
    • Hmat-1 antibody
    • HMAT1 antibody
    • HMT 1 antibody
    • HMT1 antibody
    • Mannosyltransferase 1 antibody
    • Mannosyltransferase-1 antibody
    • MT 1 antibody
    • MT-1 antibody
    • MT1 antibody
    see all

Images

  • All lanes : Anti-ALG1 antibody (ab155935) at 1/5000 dilution

    Lane 1 : Wild type Caenorhabditis elegans extract
    Lane 2 : ALG1 negative (-) Caenorhabditis elegans extract

    Lysates/proteins at 15 µg per lane.

    Secondary
    Goat anti-rabbit HRP conjugated antibody at 1/15000 dilution

    Predicted band size : 112 kDa

References

ab155935 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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