Overview

  • Product name
  • Description
    Mouse polyclonal to ALG2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human ALG2 protein (NP_149078.1, aa 1-416)

  • Positive control
    • ALG2 transfected 293T lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • Purity
    Protein G purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab69261 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 48 kDa (predicted molecular weight: 48 kDa).

Target

  • Function
    Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
  • Pathway
    Protein modification; protein glycosylation.
  • Involvement in disease
    Defects in ALG2 are the cause of congenital disorder of glycosylation type 1I (CDG1I) [MIM:607906]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
  • Sequence similarities
    Belongs to the glycosyltransferase 1 family.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 3-mannosyltransferase ALG2 antibody
    • ALG2 alpha-1,3/1,6-mannosyltransferase antibody
    • ALG2 antibody
    • ALG2_HUMAN antibody
    • Alpha 1,3 mannosyltransferase ALG2 antibody
    • Alpha-1 antibody
    • Asparagine linked glycosylation protein 2 antibody
    • Asparagine-linked glycosylation protein 2 homolog antibody
    • CDGIi antibody
    • FLJ14511 antibody
    • GDP Man:Man(1)GlcNAc(2) PP dolichol mannosyltransferase antibody
    • GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase antibody
    • hALPG2 antibody
    • NET38 antibody
    • OTTHUMP00000021785 antibody
    • OTTHUMP00000123474 antibody
    • RP11-13B9.1 antibody
    see all

Anti-ALG2 antibody images

  • All lanes : Anti-ALG2 antibody (ab69261) at 1/500 dilution

    Lane 1 : ALG2 transfected 293T lysate
    Lane 2 : Non-transfected 293T lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 48 kDa
    Observed band size : 48 kDa

References for Anti-ALG2 antibody (ab69261)

ab69261 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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