Overview

  • Product nameAnti-ALG8 antibody
    See all ALG8 primary antibodies
  • Description
    Rabbit polyclonal to ALG8
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 301-350 (LELKLLDPSQ IPRASMTSGL VQQSQHTVLP SVSPSATLIC TLIAILPSVF) of Rat ALG8 (NP_001029299).

  • Positive control
    • Rat Heart lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab110700 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 59 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionAdds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.
  • PathwayProtein modification; protein glycosylation.
  • Involvement in diseaseDefects in ALG8 are the cause of congenital disorder of glycosylation type 1H (CDG1H) [MIM:608104]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
  • Sequence similaritiesBelongs to the ALG6/ALG8 glucosyltransferase family.
  • Cellular localizationEndoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 3-glucosyltransferase antibody
    • AI447372 antibody
    • ALG 8 antibody
    • ALG8 alpha-1,3-glucosyltransferase antibody
    • alg8 antibody
    • ALG8_HUMAN antibody
    • Asparagine linked glycosylation 8 alpha 1,3 glucosyltransferase homolog antibody
    • Asparagine linked glycosylation 8 homolog yeast, alpha 1,3 glucosyltransferase antibody
    • Asparagine linked glycosylation 8 homolog S. cerevisiae, alpha 1,3 glucosyltransferase antibody
    • Asparagine-linked glycosylation protein 8 homolog antibody
    • CDG1H antibody
    • Dolichyl P Glc Glc1Man9GlcNAc2 PP dolichyl glucosyltransferase antibody
    • Dolichyl P glucose Glc1Man9GlcNAc2 PP dolichyl alpha 1,3 glucosyltransferase antibody
    • Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha 1,3 glucosyltransferase antibody
    • Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase antibody
    • Gm1089 antibody
    • HUSSY 02 antibody
    • MGC2840 antibody
    • MGC74399 antibody
    • Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha 1,3 glucosyltransferase antibody
    • Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1 antibody
    see all

Anti-ALG8 antibody images

  • Anti-ALG8 antibody (ab110700) at 1 µg/ml + Rat Heart lysate at 10 µg

    Predicted band size : 59 kDa

References for Anti-ALG8 antibody (ab110700)

ab110700 has not yet been referenced specifically in any publications.

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