Human Predicted to work with:
Recombinant fragment, corresponding to amino acids 38-282 of Human ALKBH4 (BC002820).
Human fetal spleen, fetal liver and fetal kidney lysates; Human fetal pancreas tissue.
Lyophilised:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Detects a band of approximately 36 kDa (predicted molecular weight: 34 kDa).
1/100 - 1/500.
Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation.
Widely expressed, with highest expression in pancreas, ovary and spleen.
Belongs to the alkB family.
Cytoplasm. Nucleus. Midbody. Associates with the contractile ring and midbody.