Overview

  • Product nameAnti-ALMS1 antibody
    See all ALMS1 primary antibodies
  • Description
    Rabbit polyclonal to ALMS1
  • Tested applicationsSuitable for: ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region within amino acids 1200-1250 of human ALMS1 (EAW99731.1).

  • Positive control
    • HeLa Cells.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab84892 was affinity purified using an epitope specific to ALMS1 immobilized on solid support.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab84892 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF
  • Application notesICC/IF: 1/100 - 1/500. Formaldehyde fixation and permeabilization with Triton-X 100 is recommended.

    Acetone fixation is not recommended.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPossible role in intracellular trafficking.
    • Tissue specificityExpressed in all tissues tested including adipose and pancreas. Expressed by beta-cells of the islets in the pancreas (at protein level).
    • Involvement in diseaseDefects in ALMS1 are the cause of Alstrom syndrome (ALMS) [MIM:203800]. Alstrom syndrome is a rare autosomal recessive disorder characterized by progressive cone-rod retinal dystrophy, neurosensory hearing loss, early childhood obesity and type 2 diabetes mellitus. Dilated cardiomyopathy, acanthosis nigricans, male hypogonadism, hypothyroidism, developmental delay and hepatic dysfunction can also be associated with the syndrome.
    • Developmental stageWidely expressed in fetal tissues. Detected in fetal pancreas, skeletal muscle, liver, kidney and brain (at protein level). Expressed in fetal aorta and brain.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationCytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > cilium basal body. Cytoplasm > cytoskeleton > spindle pole. Associated with centrosomes and basal body at the base of primary cilia. During mitosis localizes to both spindle poles.
    • Information by UniProt
    • Database links
    • Alternative names
      • Alms1 antibody
      • ALMS1_HUMAN antibody
      • ALSS antibody
      • Alstrom syndrome 1 antibody
      • Alstrom syndrome protein 1 antibody
      see all

    Anti-ALMS1 antibody images

    • ab84892, at a 1/250 dilution, staining ALMS1 in NBF fixed asynchronous HeLa cells by Immunocytochemistry.
      Detection by Red fluorescent goat anti-rabbit IgG highly cross adsorbed antibody used at a dilution of 1/100.

    References for Anti-ALMS1 antibody (ab84892)

    ab84892 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab84892.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"