Anti-e-LOX-3 antibody (ab118470)
Key features and details
- Rabbit polyclonal to e-LOX-3
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-e-LOX-3 antibody -
Description
Rabbit polyclonal to e-LOX-3 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Recombinant fragment corresponding to Human e-LOX-3.
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Positive control
- Human fetal lung lysate, Human fetal skin tissue
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Lyophilized:Reconstitute in 200µl Steriled Distilled Water -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituent: 1% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab118470 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 81 kDa.
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IHC-P |
1/100 - 1/500.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 81 kDa. |
IHC-P
1/100 - 1/500. |
Target
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Function
Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known. -
Tissue specificity
Predominantly expressed in skin. -
Pathway
Lipid metabolism; leukotriene D4 biosynthesis. -
Involvement in disease
Defects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE) [MIM:242100]. NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume. -
Sequence similarities
Belongs to the lipoxygenase family.
Contains 1 lipoxygenase domain.
Contains 1 PLAT domain. - Information by UniProt
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Database links
- Entrez Gene: 59344 Human
- Entrez Gene: 23801 Mouse
- Entrez Gene: 287424 Rat
- Omim: 607206 Human
- SwissProt: Q9BYJ1 Human
- SwissProt: Q9WV07 Mouse
- Unigene: 232770 Human
- Unigene: 41989 Mouse
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Alternative names
- ALOXE3 antibody
- Arachidonate lipoxygenase 3 antibody
- e LOX 3 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab118470 has been referenced in 3 publications.
- Gao MM et al. The ALOXE3 gene variants from patients with Dravet syndrome decrease gene expression and enzyme activity. Brain Res Bull 170:81-89 (2021). PubMed: 33581311
- Tang HL et al. Expression Pattern of ALOXE3 in Mouse Brain Suggests Its Relationship with Seizure Susceptibility. Cell Mol Neurobiol N/A:N/A (2020). PubMed: 33058074
- Xia Y et al. Discovery of a novel ferroptosis inducer-talaroconvolutin A-killing colorectal cancer cells in vitro and in vivo. Cell Death Dis 11:988 (2020). PubMed: 33203867