Overview

  • Product nameAnti-ALOXE3 antibody
    See all ALOXE3 primary antibodies
  • Description
    Rabbit polyclonal to ALOXE3
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant Human ALOXE3.

  • Positive control
    • Human fetal lung lysate, Human fetal skin tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab118470 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 81 kDa.
IHC-P 1/100 - 1/500.

Target

  • FunctionIntroduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known.
  • Tissue specificityPredominantly expressed in skin.
  • PathwayLipid metabolism; leukotriene D4 biosynthesis.
  • Involvement in diseaseDefects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE) [MIM:242100]. NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume.
  • Sequence similaritiesBelongs to the lipoxygenase family.
    Contains 1 lipoxygenase domain.
    Contains 1 PLAT domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • ALOXE3 antibody
    • Arachidonate lipoxygenase 3 antibody
    • e LOX 3 antibody
    • E LOX antibody
    • e-LOX-3 antibody
    • eLOX3 antibody
    • Epidermal lipoxygenase antibody
    • Epidermis-type lipoxygenase 3 antibody
    • Lipoxygenase 3 antibody
    • LOXE3_HUMAN antibody
    see all

Anti-ALOXE3 antibody images

  • Anti-ALOXE3 antibody (ab118470) at 1/500 dilution + Human fetal lung lysate

    Predicted band size : 81 kDa
  • Staining of Human ALOXE3 in a Formalin/PFA-fixed paraffin-embedded section of Human fetal skin using ab118470 at a dilution of 1/100.

References for Anti-ALOXE3 antibody (ab118470)

ab118470 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"