Overview

  • Product nameAnti-ALOXE3 antibody
    See all ALOXE3 primary antibodies
  • Description
    Mouse polyclonal to ALOXE3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human protein

  • Positive control
    • Lysate from transfected 293T cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab73091 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 80 kDa.

Target

  • FunctionIntroduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known.
  • Tissue specificityPredominantly expressed in skin.
  • PathwayLipid metabolism; leukotriene D4 biosynthesis.
  • Involvement in diseaseDefects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE) [MIM:242100]. NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume.
  • Sequence similaritiesBelongs to the lipoxygenase family.
    Contains 1 lipoxygenase domain.
    Contains 1 PLAT domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • ALOXE3 antibody
    • Arachidonate lipoxygenase 3 antibody
    • e LOX 3 antibody
    • E LOX antibody
    • e-LOX-3 antibody
    • eLOX3 antibody
    • Epidermal lipoxygenase antibody
    • Epidermis-type lipoxygenase 3 antibody
    • Lipoxygenase 3 antibody
    • LOXE3_HUMAN antibody
    see all

Anti-ALOXE3 antibody images

  • All lanes : Anti-ALOXE3 antibody (ab73091) at 1/500 dilution

    Lane 1 : ALOXE3 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP conjugated at 1/2500 dilution

    Predicted band size : 80 kDa
    Observed band size : 80 kDa

References for Anti-ALOXE3 antibody (ab73091)

ab73091 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"