Anti-alpha 1 Antichymotrypsin antibody [EPR14118(B)] (ab184567)
- Datasheet
- Specific References
- Protocols
Overview
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Product nameAnti-alpha 1 Antichymotrypsin antibody [EPR14118(B)]
See all alpha 1 Antichymotrypsin primary antibodies -
DescriptionRabbit monoclonal [EPR14118(B)] to alpha 1 Antichymotrypsin
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Host speciesRabbit
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Tested applicationsSuitable for: WBmore details
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Species reactivityReacts with: Human
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Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human alpha 1 Antichymotrypsin aa 200-300. The exact sequence is proprietary.
Database link: P01011 -
Positive control
- Human serum and Human plasma.
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General notes
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
This product is a recombinant rabbit monoclonal antibody.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
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Storage bufferPreservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol, 0.05% BSA -
PurityTissue culture supernatant
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ClonalityMonoclonal
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Clone numberEPR14118(B)
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IsotypeIgG
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Research areas
Associated products
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Related Products
Applications
Our Abpromise guarantee covers the use of ab184567 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/1000 - 1/10000. Detects a band of approximately 70 kDa (predicted molecular weight: 48 kDa). |
Target
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FunctionAlthough its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
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Tissue specificityPlasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
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Involvement in diseaseDefects in SERPINA3 may be a cause of chronic obstructive pulmonary disease (COPD) [MIM:107280].
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Sequence similaritiesBelongs to the serpin family.
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DomainThe reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
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Cellular localizationSecreted.
- Information by UniProt
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Database links
- Entrez Gene: 12 Human
- Omim: 107280 Human
- SwissProt: P01011 Human
- Unigene: 534293 Human
- Unigene: 710488 Human
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Alternative names
- SERPINA3 antibody
- AACT antibody
- AACT_HUMAN antibody
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Images
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![Western blot - Anti-alpha 1 Antichymotrypsin [EPR14118(B)] antibody (ab184567)](http://a.abcam.com/ps/products/184/ab184567/Images/ab184567-217815-ab184567wb.jpg)
Western blot - Anti-alpha 1 Antichymotrypsin [EPR14118(B)] antibody (ab184567)All lanes : Anti-alpha 1 Antichymotrypsin antibody [EPR14118(B)] (ab184567) at 1/10000 dilution
Lane 1 : Human serum
Lane 2 : Human plasma
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution
Predicted band size: 48 kDa
Protocols
References
ab184567 has not yet been referenced specifically in any publications.
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"