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alpha 1 Antichymotrypsin protein (His tag) (ab89363)

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Overview

  • Product namealpha 1 Antichymotrypsin protein (His tag)See all alpha 1 Antichymotrypsin proteins and peptides ...
  • Protein descriptionRecombinant full length Human alpha 1 Antichymotrypsin with His tag; amino acids 24-423 (421aa), 47.6kDa. Swiss ID = P01011.
  • Expression hostE. coli

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesab89363 is purified using conventional chromatography techniques.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Store in the dark. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab89363 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        SERPINA3AACTAACT_HUMAN
        ACTAlpha-1-antichymotrypsin His-Pro-lessAntichymotrypsinCell growth inhibiting gene 24/25 proteinCell growth-inhibiting gene 24/25 proteinGIG24GIG25Growth inhibiting protein 24Growth inhibiting protein 25MGC88254Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase, antitrypsin) member 3Serine (or cysteine) proteinase inhibitor clade A member 3Serine proteinase inhibitor clade A member 3Serpin A3Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 3SERPINA3
      see all
  • FunctionAlthough its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
  • Tissue specificityPlasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
  • Involvement in diseaseDefects in SERPINA3 may be a cause of chronic obstructive pulmonary disease (COPD) [MIM:107280].
  • Sequence similaritiesBelongs to the serpin family.
  • DomainThe reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P01011 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    alpha 1 Antichymotrypsin protein (His tag) images

    • SDS-PAGE - alpha 1 Antichymotrypsin protein (His tag) (ab89363)
      SDS-PAGE - alpha 1 Antichymotrypsin protein (His tag) (ab89363)
      15% SDS-PAGE showing ab89363 at approximately 47.6kDa (3µg).

    References for alpha 1 Antichymotrypsin protein (His tag) (ab89363)

    ab89363 has not yet been referenced specifically in any publications.

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