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Product Name
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alpha 1 Fetoprotein antibody [4A3]
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See all alpha 1 Fetoprotein antibodies (29)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [4A3] to alpha 1 Fetoprotein
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Immunogen
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Full length protein (purified) (Human).
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Reacts with
(species key)
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Hu
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Specificity
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ab10071 and 10072 react with different determinants of human a-fetoprotein. They do not react with albumin.
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Tested applications
(see key)
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ELISA, sELISA
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at an assay dependent dilution.
sELISA: Use at an assay dependent dilution.
Can be paired for ELISA with Mouse monoclonal [5H7] to alpha 1 Fetoprotein (HRP) (ab10072).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Secreted
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Research areas
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Developmental Biology >> Organogenesis >> Gut development >> Liver development
Cancer >> Tumor biomarkers >> Tumor antigens
Cardiovascular >> Blood >> Serum Proteins
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Relevance
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Alpha 1 Fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. Expression has been documented in human adrenal, liver, ovary, testis, and pancreas. ESTs have been isolated from normal human brain, liver/spleen, embryo and uterus tissue libraries.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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4A3
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Myeloma
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Sp2/0
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Isotype
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IgG2a
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Purity
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Protein A purified
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Storage buffer
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Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.4 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Purification notes
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Purity tested by electrophoresis.
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Form
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Liquid
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Concentration
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2.000 mg/ml
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Storage instructions
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Store at +4°C.
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Notes
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Concentration varies from lot to lot and can be provided on request.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this alpha 1 Fetoprotein antibody [4A3] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to alpha 1 Fetoprotein
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alpha 1 Fetoprotein antibody [4A3] - more information
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