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Product Name
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alpha 1 Fetoprotein protein
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Product type
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Proteins and Peptides
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Peptide
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Full length AFP purified from Human cord serum.
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Tested applications
(see key)
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ELISA, Inhib, WB
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at an assay dependent dilution.
Inhib: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Detects a band of approximately 70 kDa (predicted molecular weight: 69 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Developmental Biology >> Organogenesis >> Gut development >> Liver development
Cancer >> Tumor biomarkers >> Tumor antigens
Cardiovascular >> Blood >> Serum Proteins
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Relevance
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Alpha 1 Fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. Expression has been documented in human adrenal, liver, ovary, testis, and pancreas. ESTs have been isolated from normal human brain, liver/spleen, embryo and uterus tissue libraries.
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Storage buffer
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Preservative: None
Constituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5 Material safety datasheet (MSDS) for this product:
Glycerol MSDS
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Purification notes
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Purified from human cord serum.
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Form
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Liquid
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Concentration
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0.100 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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