Anti-alpha 1 Glycine Receptor antibody (ab26134)

Overview

  • Product nameAnti-alpha 1 Glycine Receptor antibody
    See all alpha 1 Glycine Receptor primary antibodies
  • Description
    Rabbit polyclonal to alpha 1 Glycine Receptor
  • Specificityab26134 recognises Glycine receptor alpha-1 chain precursor (GLRA1).
  • Tested applicationsELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog, Zebrafish
  • Immunogen

    Synthetic peptide derived from a region between residues 178 - 227 of human Glycine Receptor alpha 1.

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  • Positive control
    • Raji cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab26134 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/62500.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 51 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionThe glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
  • Involvement in diseaseDefects in GLRA1 are a cause of startle disease (STHE) [MIM:149400]; also known as hereditary hyperekplexia or congenital stiff-person syndrome. STHE is a genetically heterogeneous neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. Inheritance can be autosomal dominant or recessive.
  • Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
  • Cellular localizationCell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • GLRA1 antibody
    • GLRA1_HUMAN antibody
    • Glycine receptor 48 kDa subunit antibody
    • Glycine receptor alpha 1 antibody
    • Glycine receptor strychnine-binding subunit antibody
    • Glycine receptor subunit alpha-1 antibody
    • Glycine receptor, alpha 1 subunit antibody
    • HKPX1 antibody
    • STHE antibody
    see all

Anti-alpha 1 Glycine Receptor antibody images

  • Anti-alpha 1 Glycine Receptor antibody (ab26134) at 1 µg/ml + Raji cell lysate

    Predicted band size : 51 kDa

References for Anti-alpha 1 Glycine Receptor antibody (ab26134)

ab26134 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry regarding our antibody to alpha 1 glycine receptor. To my knowledge, there is no experimental data on whether this antibody will also recognise alpha2 glysine receptor. I have done a BLAST sequence alignment analogy search, a...

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