Anti-alpha 1 Antichymotrypsin antibody, prediluted (ab921)

Overview

  • Product nameAnti-alpha 1 Antichymotrypsin antibody, prediluted
    See all alpha 1 Antichymotrypsin primary antibodies
  • Description
    Rabbit polyclonal to alpha 1 Antichymotrypsin, prediluted
  • SpecificityThe antibody is specific for human alpha-1-antichymotrypsin. This antibody stains monocytes and macrophages in human tissues and does not stain any other cell type.
  • Tested applicationsSuitable for: IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
    Does not react with: Mouse, Rat, Sheep, Horse, Cow, Cat, Dog, Pig
  • Immunogen

    Alpha-1-antichymotrypsin isolated from human serum.

Properties

Applications

Our Abpromise guarantee covers the use of ab921 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
IHC-Fr
  • Application notesThis antibody has been pretitered and quality controlled to work on formalin-fixed paraffin-embedded as well as acetone fixed cryostat tissue sections.
    No further titration is required.
    We suggest an incubation period of 30-60 minutes at room temperature.
    However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user.
  • Target

    • FunctionAlthough its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
    • Tissue specificityPlasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
    • Involvement in diseaseDefects in SERPINA3 may be a cause of chronic obstructive pulmonary disease (COPD) [MIM:107280].
    • Sequence similaritiesBelongs to the serpin family.
    • DomainThe reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • SERPINA3 antibody
      • AACT antibody
      • AACT_HUMAN antibody
      • ACT antibody
      • Alpha-1-antichymotrypsin His-Pro-less antibody
      • Antichymotrypsin antibody
      • Cell growth inhibiting gene 24/25 protein antibody
      • Cell growth-inhibiting gene 24/25 protein antibody
      • GIG24 antibody
      • GIG25 antibody
      • Growth inhibiting protein 24 antibody
      • Growth inhibiting protein 25 antibody
      • MGC88254 antibody
      • Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase, antitrypsin) member 3 antibody
      • Serine (or cysteine) proteinase inhibitor clade A member 3 antibody
      • Serine proteinase inhibitor clade A member 3 antibody
      • Serpin A3 antibody
      • Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 3 antibody
      • SERPINA3 antibody
      see all

    Anti-alpha 1 Antichymotrypsin antibody, prediluted images

    • Immunohistochemical analysis of formalin-fixed paraffin-embedded human tonsil tissue sections, labelling ?-1-Antichymotrypsin with ab921.

    References for Anti-alpha 1 Antichymotrypsin antibody, prediluted (ab921)

    ab921 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"