Anti-alpha 1 Catenin (phospho S641) antibody (ab111587)


  • Product nameAnti-alpha 1 Catenin (phospho S641) antibody
    See all alpha 1 Catenin primary antibodies
  • Description
    Rabbit polyclonal to alpha 1 Catenin (phospho S641)
  • Specificityab111587 detects endogenous levels of alpha 1 Catenin only when phosphorylated at serine 641.
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic phosphopeptide derived from Human alpha 1 Catenin around the phosphorylation site of serine 641 (D-D-SP-D-F).

  • Positive control
    • Human brain tissue



Our Abpromise guarantee covers the use of ab111587 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • FunctionAssociates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
  • Tissue specificityExpressed ubiquitously in normal tissues.
  • Sequence similaritiesBelongs to the vinculin/alpha-catenin family.
  • Post-translational
  • Cellular localizationCell membrane and Cytoplasm > cytoskeleton. Cell junction > adherens junction. Cell membrane. Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alpha E-catenin antibody
    • Cadherin associated protein 102kDa antibody
    • Cadherin associated protein antibody
    • Cadherin-associated protein antibody
    • CAP 102 antibody
    • CAP102 antibody
    • Catenin (cadherin associated protein) alpha 1 102kDa antibody
    • Catenin (cadherin associated protein), alpha 1, 102kDa antibody
    • Catenin alpha 1 antibody
    • Catenin alpha-1 antibody
    • CTNA1_HUMAN antibody
    • CTNNA 1 antibody
    • Ctnna1 antibody
    • FLJ36832 antibody
    • FLJ52416 antibody
    • NY REN 13 antigen antibody
    • OTTHUMP00000224141 antibody
    • OTTHUMP00000224147 antibody
    • Renal carcinoma antigen NY REN 13 antibody
    • Renal carcinoma antigen NY-REN-13 antibody
    see all

Anti-alpha 1 Catenin (phospho S641) antibody images

  • ab111587, at a 1/50 dilution, staining alpha 1 Catenin in paraffin embedded Human brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

References for Anti-alpha 1 Catenin (phospho S641) antibody (ab111587)

ab111587 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.
We can provide the blocking peptide for antibody ab111587. One unit of peptide will cost you €180 excluding delivery charges, please let me know if you are interested in buying I will then be adding it into the catalog...

Read More