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Products:Cardiovascular >> Blood >> Serum Proteins
Overview
Product name
Anti-alpha 1 Fetoprotein antibody
See all alpha 1 Fetoprotein products (31) ...
Description
Rabbit polyclonal to alpha 1 Fetoprotein
Specificity
This antibody reacts with Alpha-1-Fetoprotein (AFP). A positive staining in the hepatocytes of fetal tissue was observed. This antibody does not react with any other cell or tissue types.
Tested applications
IHC-P, IHC-Frmore details
Cross reactivity
Reacts with
Human
Immunogen
Alpha-1-fetoprotein isolated from human cord serum
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Liquid antiserum
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Light chain type
unknown
Research areas
Developmental Biology >> Organogenesis >> Gut development >> Liver development
Cancer >> Tumor biomarkers >> Tumor antigens
Cardiovascular >> Blood >> Serum Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab9372 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: 1/50 - 1/150.(in an ABC method. Incubation for 30-60 minutes at room temperature is suggested.)
IHC-Fr: Use at an assay dependent dilution.
Target
Function
Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.
Tissue specificity
Plasma. Synthesized by the fetal liver and yolk sac.
Sequence similarities
Belongs to the ALB/AFP/VDB family.
Contains 3 albumin domains.
Developmental stage
Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma.
Post-translational
modifications
Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.
Sulfated.
Cellular localization
Secreted.
Target information above from: UniProt accessionP02771
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AFP antibody
- Alpha fetoglobulin antibody
- Alpha fetoprotein antibody
see all
Database links
- Entrez Gene: 174 Human
- Omim: 104150 Human
- SwissProt: P02771 Human
- Unigene: 518808 Human
References for Anti-alpha 1 Fetoprotein antibody (ab9372)
ab9372 has not yet been referenced specifically in any publications.
Publishing research using ab9372? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"