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Product Name
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alpha 1 Fetoprotein antibody
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See all alpha 1 Fetoprotein antibodies (29)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to alpha 1 Fetoprotein
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Immunogen
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Alpha-1-fetoprotein isolated from human cord serum
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Reacts with
(species key)
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Hu
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Specificity
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This antibody reacts with Alpha-1-Fetoprotein (AFP).
A positive staining in the hepatocytes of fetal tissue was observed.
This antibody does not react with any other cell or tissue types.
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Tested applications
(see key)
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IHC-Fr, IHC-P
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: 1/50 - 1/150. in an ABC method. Incubation for 30-60 minutes at room temperature is suggested.
IHC-Fr: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Secreted
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Research areas
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Developmental Biology >> Organogenesis >> Gut development >> Liver development
Cancer >> Tumor biomarkers >> Tumor antigens
Cardiovascular >> Blood >> Serum Proteins
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Relevance
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Alpha 1 Fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. Expression has been documented in human adrenal, liver, ovary, testis, and pancreas. ESTs have been isolated from normal human brain, liver/spleen, embryo and uterus tissue libraries.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Protein A purified
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Storage buffer
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Liquid antiserum
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Form
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Liquid
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Concentration
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2.000 mg/ml
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Storage instructions
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Store at +4°C.
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Search PubMed (MEDLINE) for references to alpha 1 Fetoprotein
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