Overview

  • Product nameAnti-alpha 1 Fetoprotein antibody [M0151611]
    See all alpha 1 Fetoprotein primary antibodies
  • Description
    Mouse monoclonal [M0151611] to alpha 1 Fetoprotein
  • SpecificityCross reactivity - alpha 1 Fetoprotein 100%.
  • Tested applicationsSuitable for: Sandwich ELISA, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Highly pure alpha 1 Fetoprotein from cord serum (Human)

  • General notesAffinity Constant: ~8.0 x 108 L/M

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab40942 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Sandwich ELISA Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution. Can be paired for ELISA with Mouse monoclonal [M803209] to alpha 1 Fetoprotein (ab40941). two site ELISA

Target

  • FunctionBinds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.
  • Tissue specificityPlasma. Synthesized by the fetal liver and yolk sac.
  • Sequence similaritiesBelongs to the ALB/AFP/VDB family.
    Contains 3 albumin domains.
  • Developmental stageOccurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma.
  • Post-translational
    modifications
    Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.
    Sulfated.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Afp antibody
    • Alpha fetoglobulin antibody
    • Alpha fetoprotein antibody
    • Alpha fetoprotein precursor antibody
    • Alpha-1-fetoprotein antibody
    • Alpha-fetoglobulin antibody
    • Alpha-fetoprotein antibody
    • alpha-fetoprotein, Hereditary persistence of, included antibody
    • FETA antibody
    • FETA_HUMAN antibody
    • Hereditary persistence of alpha fetoprotein antibody
    • HPAFP antibody
    see all

References for Anti-alpha 1 Fetoprotein antibody [M0151611] (ab40942)

This product has been referenced in:
  • Huang KW  et al. Feasibility studies for assaying alpha-fetoprotein using antibody-activated magnetic nanoparticles. Int J Nanomedicine 7:1991-6 (2012). Read more (PubMed: 22619536) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"