Human Predicted to work with:
Synthetic peptide corresponding to Human alpha 1 Sodium Potassium ATPase (phospho S16) conjugated to Keyhole Limpet Haemocyanin (KLH). Peptide sequence around phosphorylation site of serine 16 (A-V-S(p)-E-Q) derived from Human alpha 1 Sodium Potassium ATPase. Database link: P05023
293 cell extract, treated with PMA.
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
Phosphorylation on Tyr-10 modulates pumping activity.
Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.