Anti-alpha 1 Spectrin antibody [AF10] (ab86184)

Overview

  • Product nameAnti-alpha 1 Spectrin antibody [AF10]
    See all alpha 1 Spectrin primary antibodies
  • Description
    Mouse monoclonal [AF10] to alpha 1 Spectrin
  • Specificityab86184 is specific to the erythroid alpha 1 Spectrin.
  • Tested applicationsSuitable for: WB, IP, ICCmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Ghost proteins of human red blood cells.

  • General notes


    ab86184 is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab86184 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 280 kDa.
IP Use at an assay dependent dilution.
ICC Use at an assay dependent dilution.

Target

  • FunctionSpectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
  • Involvement in diseaseDefects in SPTA1 are the cause of elliptocytosis type 2 (EL2) [MIM:130600]. EL2 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
    Defects in SPTA1 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:266140]. HPP is an autosomal recessive disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.
    Defects in SPTA1 are the cause of spherocytosis type 3 (SPH3) [MIM:270970]; also known as hereditary spherocytosis type 3 (HS3). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH3 is characterized by severe hemolytic anemia. Inheritance is autosomal recessive.
  • Sequence similaritiesBelongs to the spectrin family.
    Contains 3 EF-hand domains.
    Contains 1 SH3 domain.
    Contains 21 spectrin repeats.
  • Cellular localizationCytoplasm > cytoskeleton. Cytoplasm > cell cortex.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alpha I spectrin antibody
    • EL 2 antibody
    • EL2 antibody
    • Elliptocytosis 2 antibody
    • Elliptocytosis2 antibody
    • Erythrocyte alpha spectrin antibody
    • erythrocyte antibody
    • Erythroid alpha spectrin antibody
    • Erythroid alpha-spectrin antibody
    • Erythroid spectrin alpha antibody
    • HPP antibody
    • HS3 antibody
    • Spectrin alpha chain antibody
    • Spectrin alpha chain erythrocyte antibody
    • Spectrin alpha erythrocytic 1 antibody
    • SPH3 antibody
    • SPTA 1 antibody
    • SPTA antibody
    • SPTA1 antibody
    • SPTA1_HUMAN antibody
    see all

References for Anti-alpha 1 Spectrin antibody [AF10] (ab86184)

ab86184 has not yet been referenced specifically in any publications.

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