The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 5 µg/ml.
Use a concentration of 10 µg/ml.
Use a concentration of 0.5 µg/ml. Detects a band of approximately 20 kDa.
FunctionMay contribute to the transparency and refractive index of the lens.
Tissue specificityLens as well as other tissues.
Involvement in diseaseDefects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients.
Sequence similaritiesBelongs to the small heat shock protein (HSP20) family.
Cellular localizationCytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
References for Anti-Alpha B Crystallin (phospho S19) antibody (ab5597)
This product has been referenced in:
Lambrecht S et al. Differential expression of alphaB-crystallin and evidence of its role as a mediator of matrix gene expression in osteoarthritis. Arthritis Rheum60:179-88 (2009).
Read more (PubMed: 19116904) »