Anti-alpha Internexin antibody (ab71230)

Overview

• Product nameAnti-alpha Internexin antibodySee all alpha Internexin primary antibodies ...
• Description
  Rabbit polyclonal to alpha Internexin
• Tested applicationsELISA, WB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide from the center region of human alpha Internexin conjugated to KLH

• Positive control293 cell lysate transiently transfected with the alpha Internexin gene.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityProtein A purified
• Purification notesab71230 is purified through a protein A column, followed by peptide affinity purification.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Neuroscience
  • Cell Adhesion Proteins
  • Cytoskeletal Proteins
  • Intermediate Filaments

Applications

Target

• FunctionClass-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.
• Tissue specificityFound predominantly in adult CNS.
• Sequence similaritiesBelongs to the intermediate filament family.
• Developmental stageExpressed in brain as early as the 16th week of gestation, and increased rapidly and reached a steady state level by the 18th week of gestation.
• Post-translational
  modificationsO-glycosylated.
  Phosphorylated upon DNA damage, probably by ATM or ATR.

Target information above from: UniProt accession Q16352 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 9118 Human
  • Entrez Gene: 9118 Human
  • Omim: 605338 Human
  • SwissProt: Q16352 Human
  • SwissProt: Q16352 Human
  • Unigene: 500916 Human

• Alternative names
  66 kDa neurofilament protein antibodyAINX_HUMAN antibodyAlpha Inx antibody

  Alpha-internexin antibodyAlpha-Inx antibodyINA antibodyInternexin neuronal intermediate filament protein alpha antibodyMGC12702 antibodyNEF 5 antibodyNEF5 antibodyNeurofilament 5 (66kD) antibodyNeurofilament 5 antibodyNeurofilament 66 antibodyNeurofilament 66 tax binding protein antibodyNeurofilament-66 antibodyNF 66 antibodyNF-66 antibodyNF66 antibodyTXBP 1 antibodyTXBP1 antibody

  see all

Anti-alpha Internexin antibody images

• 

  Western blot - alpha Internexin antibody (ab71230)
  All lanes : Anti-alpha Internexin antibody (ab71230) at 1/50 dilution
  
  Lane 1 : 293 cell lysates (nontransfected)
  Lane 2 : 293 cell lysates transiently transfected with the alpha Internexin gene
  
  Lysates/proteins at 2 µg per lane.
  
  
  Predicted band size : 55 kDa
  Observed band size : 64 kDa (why is the actual band size different from the predicted?)
  Additional bands at : 72 kDa. We are unsure as to the identity of these extra bands.