Anti-alpha Tubulin antibody (ab106375)
- Product nameAnti-alpha Tubulin antibodySee all alpha Tubulin primary antibodies ...
- DescriptionChicken polyclonal to alpha Tubulin
- Tested applicationsWB more details
- Species reactivityReacts with: Mouse, Rat, Human
A 16 amino acid synthetic peptide near the amino terminus of Human alpha Tubulin (CAA25855).
- Positive control
- Rat brain tissue lysate.
- Storage instructionsStore at +4°C.
- Storage bufferPreservative: 0.02% Sodium Azide
- Concentration information loading...
- PurityImmunogen affinity purified
- Clonality Polyclonal
- Research Areas
Our Abpromise guarantee covers the use of ab106375 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||WB: Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 50 kDa.|
- FunctionTubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
- Sequence similaritiesBelongs to the tubulin family.
modificationsSome glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.
Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling.
- Cellular localizationCytoplasm > cytoskeleton.
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Anti-alpha Tubulin antibody images
Lane 1 : Anti-alpha Tubulin antibody (ab106375) at 0.5 µg/ml
Lane 2 : Anti-alpha Tubulin antibody (ab106375) at 1 µg/ml
Lane 1 : Rat brain tissue lysate
Lane 2 : Rat brain tissue lysate
Lysates/proteins at 15 µg per lane.
Predicted band size : 50 kDa
References for Anti-alpha Tubulin antibody (ab106375)
ab106375 has not yet been referenced specifically in any publications.