Anti-alpha A + alpha B Crystallin antibody (ab63998)

Overview

  • Product nameAnti-alpha A + alpha B Crystallin antibody
    See all Alpha A + alpha B Crystallin primary antibodies
  • Description
    Rabbit polyclonal to alpha A + alpha B Crystallin
  • Tested applicationsSuitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Cow, Human
  • Immunogen

    Bovine alpha/beta crystalin which has greater than 80% homology with human alpha/beta crystalin.

  • Positive control
    • Stains Rosenthal fibre accumulation in astrocytes in human neurological trauma.

Properties

Applications

Our Abpromise guarantee covers the use of ab63998 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/1000 - 1/4000.
ICC/IF 1/100 - 1/400.

Target

  • RelevanceCrystallins are separated into two classes: taxon specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Alpha crystallins are composed of two gene products: alpha A and alpha B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture.
  • Cellular localizationCytoplasmic
  • Database links
  • Alternative names
    • Alpha crystallin A chain antibody
    • Alpha crystallin B chain antibody
    • CRYA1 antibody
    • CRYA2 antibody
    • CRYAA antibody
    • CRYAB antibody
    • Heat shock protein beta 4 antibody
    • Heat shock protein beta 5 antibody
    • HspB4 antibody
    • HspB5 antibody
    • Rosenthal fiber component antibody
    see all

Anti-alpha A + alpha B Crystallin antibody images

  • Ab63998 (1:2000) staining of human brain tissue showing aß crystallin accumulation in Rosenthal fibres. Secondary antibody biotinylated Goat anti-rabbit (1/2000). (A) Shows the early stages of aß crystallin accumulation in astrocytes, (B) astrocyte begins to hypertrophy with aß crystallin accumulation, (C) the astrocyte begins to further hypertrophy and cell structure is lost.

References for Anti-alpha A + alpha B Crystallin antibody (ab63998)

ab63998 has not yet been referenced specifically in any publications.

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