Overview

  • Product nameAnti-alpha A Crystallin antibody
    See all alpha A Crystallin primary antibodies
  • Description
    Rabbit polyclonal to alpha A Crystallin
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Cow, Human
    Predicted to work with: Chicken
  • Immunogen

    Synthetic peptide derived from sequence near the carboxy-terminus of human alpha A Crystallin, conjugated to KLH

  • Positive control
    • Bovine alpha A Crystallin protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab69552 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 20 kDa.
IP 1/100.

Target

  • FunctionMay contribute to the transparency and refractive index of the lens.
  • Involvement in diseaseDefects in CRYAA are a cause of cataract autosomal dominant (ADC) [MIM:604219]. Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Cataract is the most common treatable cause of visual disability in childhood.
  • Sequence similaritiesBelongs to the small heat shock protein (HSP20) family.
  • Post-translational
    modifications
    O-glycosylated; contains N-acetylglucosamine side chains.
    Deamidation of Asn-101 in lens occurs mostly during the first 30 years of age, followed by a small additional amount of deamidation (approximately 5%) during the next approximately 38 years, resulting in a maximum of approximately 50% deamidation during the lifetime of the individual.
    Phosphorylation on Ser-122 seems to be developmentally regulated. Absent in the first months of life, it appears during the first 12 years of human lifetime. The relative amount of phosphorylated form versus unphosphorylated form does not change over the lifetime of the individual.
  • Cellular localizationCytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
  • Information by UniProt
  • Database links
  • Alternative names
    • Acry 1 antibody
    • Alpha crystallin A chain antibody
    • Alpha-crystallin A chain antibody
    • CRYA 1 antibody
    • CRYA1 antibody
    • CRYAA antibody
    • CRYAA_HUMAN antibody
    • Crystallin alpha 1 antibody
    • Crystallin alpha A antibody
    • Heat shock protein beta 4 antibody
    • Heat shock protein beta-4 antibody
    • HSPB 4 antibody
    • HspB4 antibody
    • short form antibody
    • Zonular Central Nuclear Cataract antibody
    see all

Anti-alpha A Crystallin antibody images

  • Anti-alpha A Crystallin antibody (ab69552) at 1/1000 dilution + bovine alpha A Crystallin protein

    Predicted band size : 20 kDa
    Observed band size : 20 kDa
  • All lanes : Anti-alpha A Crystallin antibody (ab69552) at 1/1000 dilution

    Lane 1 : Crystalline, alpha native bovine protein
    Lane 2 : Crystalline alpha A native bovine protein
    Lane 3 : Crytalline alpha B native bovine protein
    Lane 4 : Crystalline beta native bovine protein


    Predicted band size : 20 kDa

References for Anti-alpha A Crystallin antibody (ab69552)

ab69552 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab69552.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"