Anti-alpha + beta Synuclein antibody (ab21975)

Overview

  • Product name
    Anti-alpha + beta Synuclein antibody
    See all alpha + beta Synuclein primary antibodies
  • Description
    Sheep polyclonal to alpha + beta Synuclein
  • Specificity
    Immunogen sequence is 100% identical to alpha and beta and is similar to a lesser extent to gamma synuclein. This antibody cross reacts with beta and alpha synuclein but not to gamma synculein.
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken
  • Immunogen

    Synthetic peptide corresponding to Human alpha + beta Synuclein.
    Sequence:

    AKEGVVAAAEKTKQGV

  • General notes


    This antibody achieves excellent staining of Lewy bodies in Parkinson’s disease and Dementia with Lewy bodies disease tissue and gives excellent staining of glial inclusions in Multi System Atrophy tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab21975 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/1000 - 1/4000.
WB 1/2000 - 1/8000. Predicted molecular weight: 14 kDa.

Target

  • Relevance
    Synucleins are small soluble proteins expressed primarily in neural tissues and in certain tumors. The family includes 3 known proteins, alpha synuclein, beta synuclein and gamma synuclein. All synucleins have in common a highly conserved alpha helical lipid binding motif with similarity to the class A2 lipid binding domains of the exchangeable apolipoproteins. The alpha and beta synuclein proteins are found primarily in brain tissue, where they are seen mainly in pre synaptic terminals. Alpha synuclein is believed to be a major component of Lewy bodies in Parkinson’s disease. Mutations in alpha synuclein are associated with rare familial cases of early onset Parkinson’s disease, Alzheimer’s disease and several other neurodegenerative illnesses.
  • Cellular localization
    Cytoplasmic. Membrane bound in dopaminergic neurons. Also found in the nucleus.
  • Database links
  • Alternative names
    • Alpha synuclein antibody
    • Beta synuclein antibody
    • NACP antibody
    • Non A beta component of AD amyloid antibody
    • PARK1 antibody
    • PARK4 antibody
    • PD1 antibody
    • SNCA antibody
    • SNCB antibody
    • Synuclein alpha antibody
    • Synuclein beta antibody
    see all

Images

  • Staining of Lewy body in Dementia with Lewy body disease tissue. Primary antibody ab21975 at 1/1000, secondary antibody biotinylated Donkey and sheep followed by Vector ABC and DAB substrate.

References

ab21975 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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