Overview

  • Product name
    α-Bungarotoxin
  • Description
    Subtype-selective α7 nAChR antagonist
  • Biological description
    Irreversible antagonist of nicotinic acethylcholine receptors (nAChRs). 74-aa polypeptide derived from the venom of the banded krait, Bungarus multicinctus. Selective for α7 receptors over α3β4 receptors (IC50 values are 1.6 nM and >3 μM, respectively). Blocks neuromuscular transmission. Inhibits opening of nicotinic receptor-associated ion channels.

Properties

References

This product has been referenced in:
  • Gotti C & Clementi F Neuronal nicotinic receptors: from structure to pathology. Prog Neurobiol 74:363-96 (2004). Read more (PubMed: 15649582) »
  • Marinou M & Tzartos SJ Identification of regions involved in the binding of alpha-bungarotoxin to the human alpha7 neuronal nicotinic acetylcholine receptor using synthetic peptides. Biochem J 372:543-54 (2003). Read more (PubMed: 12614199) »
  • Colquhoun LM & Patrick JW Pharmacology of neuronal nicotinic acetylcholine receptor subtypes. Adv Pharmacol 39:191-220 (1997). Read more (PubMed: 9160116) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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