α-Methyl 5-hydroxytryptamine maleate (ab120555)

Overview

  • Product name
    α-Methyl 5-hydroxytryptamine maleate
  • Description
    5-HT2A/2C receptor agonist
  • Biological description
    5-HT2A/2C receptor agonist (Ki values are 4.6 and 8.3 nM, respectively in human receptors). Potent antinociceptive effects.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Song Z  et al. Spinal 5-HT receptors that contribute to the pain-relieving effects of spinal cord stimulation in a rat model of neuropathy. Pain 152:1666-73 (2011). Read more (PubMed: 21514998) »
  • Kommalage M & Höglund AU Involvement of spinal serotonin receptors in the regulation of intraspinal acetylcholine release. Eur J Pharmacol 509:127-34 (2005). Read more (PubMed: 15733547) »
  • Sasaki M  et al. Antinociception with intrathecal alpha-methyl-5-hydroxytryptamine, a 5-hydroxytryptamine 2A/2C receptor agonist, in two rat models of sustained pain. Anesth Analg 96:1072-8, table of contents (2003). Read more (PubMed: 12651663) »
  • May JA  et al. Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys. J Pharmacol Exp Ther 306:301-9 (2003). Read more (PubMed: 12676887) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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