5-HT2A/2C receptor agonist (Ki values are 4.6 and 8.3 nM, respectively in human receptors). Potent antinociceptive effects.
α-Methyl 5-hydroxytryptamine maleate
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Sasaki M et al. Antinociception with intrathecal alpha-methyl-5-hydroxytryptamine, a 5-hydroxytryptamine 2A/2C receptor agonist, in two rat models of sustained pain. Anesth Analg96:1072-8, table of contents (2003).
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May JA et al. Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys. J Pharmacol Exp Ther306:301-9 (2003).
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