Overview

  • Product name
  • Description
    Rabbit polyclonal to alpha MSH
  • Specificity
    Anti-a-MSH cross-reacts with des-Ac-a-MSH and [Val-OH13]-a-MSH. Minimal cross-reactivity is observed with human ACTH (1-39) and ACTH (1-24).
  • Tested applications
    Suitable for: RIAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic human MSH alpha peptide conjugated to bovine serum albumin. The mid-region sequence of MSH alpha (amino acids 4-10) is identical to the ACTH and MSH beta sequences and highly conserved in the MSH gamma sequence.

  • General notes
    Affinity constant Ka: at least 1x109 L/M

Properties

Applications

Our Abpromise guarantee covers the use of ab50013 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
RIA
  • Application notes
    RIA: 1/3000 (2nd antibody and polyethylene glycol method) using 5-7pg of 125I-a-MSH.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      Melanocyte-stimulating hormone belongs to a group called the melanocortins. This group includes ACTH, alpha-MSH, beta-MSH and gamma-MSH; these peptides are all cleavage products of a large precursor peptide called pro-opiomelanocortin (POMC). Alpha-MSH is the most important melanocortin for pigmentation. It increases the pigmentation of skin by increasing melanin production in melanocytes.
    • Cellular localization
      Secreted
    • Database links
    • Alternative names
      • Alpha MSH antibody
      • Melanotropin alpha antibody
      • POMC antibody
      • proopiomelanocortin antibody

    References

    ab50013 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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