Anti-Alpha Skeletal Muscle Actin antibody [5C5.F8.C7], prediluted (ab52332)


  • Product nameAnti-Alpha Skeletal Muscle Actin antibody [5C5.F8.C7], prediluted
    See all Alpha Skeletal Muscle Actin primary antibodies
  • Description
    Mouse monoclonal [5C5.F8.C7] to Alpha Skeletal Muscle Actin, prediluted
  • SpecificityThis antibody is highly specific and shows no cross-reaction with smooth muscle actin. It reacts with sarcomeric actins of normal tissues and neoplasms derived from such tissues (i.e. rhabdomyosarcomas).
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Rabbit, Guinea pig
  • Immunogen

    A synthetic peptide derived from N-terminal of human alpha skeletal muscle isoform of actin; acetylated at the N-terminus.

  • Positive control
    • Skeletal muscle tissue



Our Abpromise guarantee covers the use of ab52332 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesIHC-P: Ready-to-use for 30 min at RT. No special pretreatment is required for the immunohistochemical staining of formalin/paraffin tissues.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionActins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
    • Involvement in diseaseDefects in ACTA1 are the cause of nemaline myopathy type 3 (NEM3) [MIM:161800]. A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. The phenotype at histological level is variable. Some patients present areas devoid of oxidative activity containg (cores) within myofibers. Core lesions are unstructured and poorly circumscribed.
      Defects in ACTA1 are a cause of myopathy congenital with excess of thin myofilaments (MPCETM) [MIM:161800]. A congenital muscular disorder characterized at histological level by areas of sarcoplasm devoid of normal myofibrils and mitochondria, and replaced with dense masses of thin filaments. Central cores, rods, ragged red fibers, and necrosis are absent.
      Defects in ACTA1 are a cause of congenital myopathy with fiber-type disproportion (CFTD) [MIM:255310]; also known as congenital fiber-type disproportion myopathy (CFTDM). CFTD is a genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy. However, these findings are not specific and can be found in many different myopathic and neuropathic conditions.
    • Sequence similaritiesBelongs to the actin family.
    • Cellular localizationCytoplasm > cytoskeleton.
    • Information by UniProt
    • Database links
    • Alternative names
      • a actin antibody
      • ACTA antibody
      • ACTA1 antibody
      • ACTC antibody
      • ACTC1 antibody
      • Actin alpha cardiac muscle antibody
      • Actin, alpha skeletal muscle antibody
      • ACTS_HUMAN antibody
      • Alpha actin 1 antibody
      • Alpha-actin-1 antibody
      • ASMA antibody
      • Cardiac muscle alpha actin 1 antibody
      • MPFD antibody
      • Skeletal muscle alpha actin 1 antibody
      see all

    Anti-Alpha Skeletal Muscle Actin antibody [5C5.F8.C7], prediluted images

    • Skeletal muscle stained with ab52332.

    References for Anti-Alpha Skeletal Muscle Actin antibody [5C5.F8.C7], prediluted (ab52332)

    ab52332 has not yet been referenced specifically in any publications.

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