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alpha smooth muscle Actin protein (His tag) (ab134555)

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Overview

  • Product namealpha smooth muscle Actin protein (His tag)See all alpha smooth muscle Actin proteins and peptides ...
  • Protein descriptionRecombinant full length Human alpha smooth muscle Actin (amino acids 3-377) with N terminal His tag; 400 amino acids with tag, Predicted MWt 44.4 kDa (NP_001604).
  • Uniprot accessionP62736
  • Molecular weight44.400kDa inclusive of tags
  • Protein length375 amino acids
  • Expression hostE. coli

    • Properties

  • Purity> 85 % by SDS-PAGE
  • Purification notesab134555 is purified using conventional chromatography techniques.
  • Mass spectrometryMALDI-TOF
  • FormLiquid
  • Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferpH: 8.00
    Constituents: 0.32% Tris HCl, 10% Glycerol, 0.88% Sodium chloride
  • Concentration information loading...
  • Sequence notesMGSSHHHHHHSSGLVPRGSHMGSHMEEEDSTALVCDNGSG LCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVG DEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELR VAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVA IQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAI MRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEK LCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERF RCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYA NNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPER KYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab134555 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    MS MS: Use at an assay dependent concentration.
    SDS-PAGE SDS-PAGE: Use at an assay dependent concentration.
  • Application notesThis peptide can be used with studies using ab137734 and ab150301.

    • Protein info

    • Alternative names
        AAT6ACTA_HUMANACTA2
        Actin alpha 2 smooth muscle aortaActin aortic smooth muscleActin, aortic smooth muscleACTSAACTVSAlpha 2 actinAlpha actin 2Alpha cardiac actinAlpha-actin-2Cell growth inhibiting gene 46 proteinCell growth-inhibiting gene 46 proteinGIG46Growth inhibiting gene 46MYMY5
      see all
  • FunctionActins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
  • Involvement in diseaseDefects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
  • Sequence similaritiesBelongs to the actin family.
  • Cellular localizationCytoplasm > cytoskeleton.

    • Target information above from: UniProt accession P62736 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    alpha smooth muscle Actin protein (His tag) images

    • SDS-PAGE - alpha smooth muscle Actin protein (His tag) (ab134555)
      SDS-PAGE - alpha smooth muscle Actin protein (His tag) (ab134555)
      15% SDS-PAGE analysis of 3 µg ab134555.

    References for alpha smooth muscle Actin protein (His tag) (ab134555)

    ab134555 has not yet been referenced specifically in any publications.

    Publishing research using ab134555 ? Please let us know so that we can cite the reference in this datasheet

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