Anti-Alpha-synuclein antibody [4D6] (ab1903)

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ab1903 has been referenced in 28 publications.

  • Gerson JE  et al. Tau oligomers mediate a-synuclein toxicity and can be targeted by immunotherapy. Mol Neurodegener 13:13 (2018). PubMed: 29544548
  • Wang J  et al. Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration. Sci Rep 7:11323 (2017). WB . PubMed: 28900170
  • Landeck N  et al. A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein. Mol Neurodegener 11:61 (2016). PubMed: 27549140
  • Migdalska-Richards A  et al. Ambroxol effects in glucocerebrosidase and a-synuclein transgenic mice. Ann Neurol 80:766-775 (2016). WB ; Mouse . PubMed: 27859541
  • Maekawa T  et al. Leucine-rich repeat kinase 2 (LRRK2) regulates a-synuclein clearance in microglia. BMC Neurosci 17:77 (2016). Mouse . PubMed: 27903237
  • Guo YJ  et al. Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of a-synuclein via SIRT1-deacetylated LC3. Mol Nutr Food Res 60:2161-2175 (2016). PubMed: 27296520
  • Ren Q  et al. Surgery plus anesthesia induces loss of attention in mice. Front Cell Neurosci 9:346 (2015). WB ; Mouse . PubMed: 26441522
  • Wu F  et al. Rotenone impairs autophagic flux and lysosomal functions in Parkinson's disease. Neuroscience 284:900-11 (2015). PubMed: 25446361
  • Hou YS  et al. Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation. Mol Cell Biol 35:2740-51 (2015). PubMed: 26031332
  • Zhang L  et al. Icariin reduces a-synuclein over-expression by promoting a-synuclein degradation. Age (Dordr) 37:9811 (2015). PubMed: 26169945
  • Bétemps D  et al. Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological a-synuclein by enhanced ELISA. Acta Neuropathol Commun 2:29 (2014). PubMed: 24624994
  • Meli G  et al. Conformational targeting of intracellular Aß oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum. Nat Commun 5:3867 (2014). PubMed: 24861166
  • Sagi Y  et al. Nitric oxide regulates synaptic transmission between spiny projection neurons. Proc Natl Acad Sci U S A 111:17636-41 (2014). PubMed: 25413364
  • Amschl D  et al. Time course and progression of wild type a-synuclein accumulation in a transgenic mouse model. BMC Neurosci 14:6 (2013). ICC/IF ; Human . PubMed: 23302418
  • Tomás-Zapico C  et al. a-Synuclein accumulates in huntingtin inclusions but forms independent filaments and its deficiency attenuates early phenotype in a mouse model of Huntington's disease. Hum Mol Genet 21:495-510 (2012). Mouse . PubMed: 22045698
  • Powers BE  et al. Axonal thinning and extensive remyelination without chronic demyelination in spinal injured rats. J Neurosci 32:5120-5 (2012). PubMed: 22496557
  • Inoue K  et al. Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener 7:48 (2012). IHC . PubMed: 22998728
  • Yanamandra K  et al. a-Synuclein Reactive Antibodies as Diagnostic Biomarkers in Blood Sera of Parkinson's Disease Patients. PLoS One 6:e18513 (2011). WB ; Human . PubMed: 21541339
  • Mulcahy P  et al. Characterisation of a novel model of Parkinson's disease by intra-striatal infusion of the pesticide rotenone. Neuroscience 181:234-42 (2011). PubMed: 21277943
  • Herzig MC  et al. LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice. Hum Mol Genet 20:4209-23 (2011). IHC-P ; Mouse . PubMed: 21828077
  • Candela P  et al. Apical-to-basolateral transport of amyloid-ß peptides through blood-brain barrier cells is mediated by the receptor for advanced glycation end-products and is restricted by P-glycoprotein. J Alzheimers Dis 22:849-59 (2010). WB, ICC ; Rat . PubMed: 20858979
  • Chaves RS  et al. Protein aggregation containing beta-amyloid, alpha-synuclein and hyperphosphorylated tau in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure. BMC Neurosci 11:144 (2010). WB, ICC ; Rat . PubMed: 21067569
  • Su B  et al. Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease. Mol Neurodegener 4:32 (2009). IHC-P ; Human . PubMed: 19627592
  • Westerlund M  et al. Cerebellar {alpha}-synuclein levels are decreased in Parkinson's disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material. FASEB J : (2008). PubMed: 18606870
  • Ekstrand MI  et al. Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Proc Natl Acad Sci U S A 104:1325-30 (2007). IHC-FoFr ; Mouse . PubMed: 17227870
  • Li X  et al. Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. J Neurochem 103:238-47 (2007). PubMed: 17623048
  • Austin SA  et al. Alpha-synuclein expression modulates microglial activation phenotype. J Neurosci 26:10558-63 (2006). WB ; Mouse . PubMed: 17035541
  • Castagnet PI  et al. Fatty acid incorporation is decreased in astrocytes cultured from alpha-synuclein gene-ablated mice. J Neurochem 94:839-49 (2005). WB ; Mouse . PubMed: 16033426


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