Overview

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab170260 is purified through a Protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab170260 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 23 kDa.

Target

  • Function
    Isoform 1: FAD-dependent sulfhydryl oxidase. Within the mitochondrial intermembrane space, participates in a chain of disulfide exchange reactions with MIA40, that generate disulfide bonds in a number of resident proteins with twin Cx3C and Cx9C motifs.
    Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.
  • Tissue specificity
    Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle.
  • Involvement in disease
    Defects in GFER are a cause of mitochondrial progressive myopathy with congenital cataract hearing loss and developmental delay (MPMCHD) [MIM:613076]; also called combined mitochondrial complex deficiency.
  • Sequence similarities
    Contains 1 ERV/ALR sulfhydryl oxidase domain.
  • Cellular localization
    Mitochondrion intermembrane space and Cytoplasm. Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • ALR_HUMAN antibody
    • Augmenter of liver regeneration antibody
    • ERV1 antibody
    • ERV1 homolog antibody
    • Erv1 like growth factor antibody
    • FAD-linked sulfhydryl oxidase ALR antibody
    • GFER antibody
    • Growth factor augmenter of liver regeneration antibody
    • Growth factor erv1 like antibody
    • Hepatic regenerative stimulation substance antibody
    • Hepatopoietin antibody
    • Hepatopoietin protein antibody
    • hERV1 antibody
    • HPO antibody
    • HPO1 antibody
    • HPO2 antibody
    • HSS antibody
    see all

Images

  • Anti-ALR antibody (ab170260) at 1/100 dilution + HepG2 cell line lysate at 35 µg

    Predicted band size : 23 kDa

References

ab170260 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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