Overview

  • Product name
    Anti-ALR antibody - C-terminal
    See all ALR primary antibodies
  • Description
    Rabbit polyclonal to ALR - C-terminal
  • Tested applications
    Suitable for: WB, Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human ALR (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: P55789

  • Positive control
    • NIH3T3 cell line lysate; HepG2 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab170507 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Predicted molecular weight: 23 kDa.
Flow Cyt 1/10 - 1/50. ab171870-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

Target

  • Function
    Isoform 1: FAD-dependent sulfhydryl oxidase. Within the mitochondrial intermembrane space, participates in a chain of disulfide exchange reactions with MIA40, that generate disulfide bonds in a number of resident proteins with twin Cx3C and Cx9C motifs.
    Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.
  • Tissue specificity
    Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle.
  • Involvement in disease
    Defects in GFER are a cause of mitochondrial progressive myopathy with congenital cataract hearing loss and developmental delay (MPMCHD) [MIM:613076]; also called combined mitochondrial complex deficiency.
  • Sequence similarities
    Contains 1 ERV/ALR sulfhydryl oxidase domain.
  • Cellular localization
    Mitochondrion intermembrane space and Cytoplasm. Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • ALR_HUMAN antibody
    • Augmenter of liver regeneration antibody
    • ERV1 antibody
    • ERV1 homolog antibody
    • Erv1 like growth factor antibody
    • FAD-linked sulfhydryl oxidase ALR antibody
    • GFER antibody
    • Growth factor augmenter of liver regeneration antibody
    • Growth factor erv1 like antibody
    • Hepatic regenerative stimulation substance antibody
    • Hepatopoietin antibody
    • Hepatopoietin protein antibody
    • hERV1 antibody
    • HPO antibody
    • HPO1 antibody
    • HPO2 antibody
    • HSS antibody
    see all

Images

  • Flow Cytometric analysis of HepG2 cells labeling ALR with ab170507 at 1/10 dilution (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

  • Anti-ALR antibody - C-terminal (ab170507) at 1/50 dilution + NIH3T3 cell line lysate at 35 µg

    Predicted band size : 23 kDa

References

ab170507 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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