Overview

  • Product name
  • Description
    Rabbit polyclonal to ALS2CL
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide from N terminal residues of Human ALS2CL protein (NM_147129.3).

  • Positive control
    • Mouse kidney lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab119937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 108 kDa (predicted molecular weight: 22, 23, 53, 85, 108 kDa).

Target

  • Function
    Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.
  • Tissue specificity
    Expressed in heart and kidney.
  • Sequence similarities
    Contains 8 MORN repeats.
    Contains 1 VPS9 domain.
  • Cellular localization
    Cytoplasm. Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • AL2CL_HUMAN antibody
    • ALS2 C-terminal like antibody
    • ALS2 C-terminal-like protein antibody
    • Als2cl antibody
    • DKFZp686I0110 antibody
    • DKFZp686P238 antibody
    • FLJ36525 antibody
    • MGC129698 antibody
    • RN49018 antibody
    see all

Images

References

ab119937 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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