Overview

  • Product name
  • Description
    Goat polyclonal to ALS2CR2
  • Specificity
    This is expected to recognise both human isoforms: ILPIP alpha (NP_061041) and ILPIP beta (AAF71042).
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    CDFPDEKDSYWEF

    , corresponding to amino acids 406-418 of Human ALS2CR2.

  • Positive control
    • Human heart or liver lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab4122 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3 - 5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 35 kDa (predicted molecular weight: 47 kDa).Can be blocked with Human ALS2CR2 peptide (ab22984).

Target

  • Function
    Pseudokinase which, in complex with CAB39, binds to and activates STK11. Relocates STK11 from the nucleus to the cytoplasm. Plays an essential role in STK11-mediated G1 cell cycle arrest.
  • Tissue specificity
    Highly expressed in heart, skeletal muscle, testis, liver and colon.
  • Sequence similarities
    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 protein kinase domain.
  • Domain
    The protein kinase domain is predicted to be catalytically inactive.
  • Cellular localization
    Nucleus. Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • ALS2 chromosome region gene 2 antibody
    • ALS2CR2 antibody
    • Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 2 antibody
    • Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein antibody
    • CALS 21 antibody
    • CALS-21 antibody
    • ILP interacting protein ILPIPA antibody
    • ILP-interacting protein antibody
    • ILPIP antibody
    • ILPIPA antibody
    • Likely ortholog of mouse polyploidy associated protein kinase antibody
    • PAPK antibody
    • PRO1038 antibody
    • Pseudokinase ALS2CR2 antibody
    • STE20-related kinase adapter protein beta antibody
    • STRAB_HUMAN antibody
    • STRAD beta antibody
    • STRADB antibody
    see all

Images



  • Predicted band size : 47 kDa


    ab4122 at a concentration of 1µg/ml staining ALS2CR2 in human heart lysate (RIPA buffer, 30µg total protein per lane) by Western blot. Primary incubated for 1 hour and detected by chemiluminescence.
  • ab4122 (3.8 µg/ml) staining ALS2CR2 in myocardial fibers in a transverse section of paraffin-embedded human heart following steamed antigen retrieval with citrate buffer pH6.

References

ab4122 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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