Overview

  • Product nameAnti-ALX4 antibody
    See all ALX4 primary antibodies
  • Description
    Rabbit polyclonal to ALX4
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Guinea pig, Cow, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 151-200 (EPELPPDSEP VGMDNSYLSV KETGAKGPQD RASAEIPSPL EKTDSESNKG) of Mouse ALX4 (NP_031468).

  • Positive control
    • Mouse brain tissue lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab104298 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 44 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionTranscription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development.
  • Tissue specificityExpression is likely to be restricted to bone. Found in parietal bone.
  • Involvement in diseaseDefects in ALX4 are the cause of parietal foramina 2 (PFM2) [MIM:609597]; also known as foramina parietalia permagna (FPP). PFM2 is an autosomal dominant disease characterized by oval defects of the parietal bones caused by deficient ossification around the parietal notch, which is normally obliterated during the fifth fetal month. PFM2 is also a clinical feature of Potocki-Shaffer syndrome.
    Defects in ALX4 are the cause of frontonasal dysplasia type 2 (FND2) [MIM:613451]. The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline.
    Involved in Potocki-Shaffer syndrome (PSS) [MIM:601224]. PSS is a contiguous gene syndrome caused by deletion of the 11p11.2 region.
  • Sequence similaritiesBelongs to the paired homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alx4 antibody
    • ALX4_HUMAN antibody
    • Aristaless like homeobox 4 antibody
    • FND2 antibody
    • FPP antibody
    • homeobox protein aristaless like 4 antibody
    • Homeobox protein aristaless-like 4 antibody
    • homeodomain transcription factor ALX4 antibody
    • KIAA1788 antibody
    • PFM1 antibody
    • PFM2 antibody
    see all

Anti-ALX4 antibody images

  • Anti-ALX4 antibody (ab104298) at 1 µg/ml + Mouse brain tissue lysate at 10 µg

    Predicted band size : 44 kDa

References for Anti-ALX4 antibody (ab104298)

ab104298 has not yet been referenced specifically in any publications.

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