Overview

  • Product name
    AM251
  • Description
    CB1 receptor antagonist / inverse agonist
  • Biological description
    Cannabinoid CB1 receptor antagonist / inverse agonist (Ki = 7.5 nM). Displays 306-fold selectivity over CB2 receptors. Anorectic and antidepressant in vivo.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Shearman LP  et al. Antidepressant-like and anorectic effects of the cannabinoid CB1 receptor inverse agonist AM251 in mice. Behav Pharmacol 14:573-82 (2003). Read more (PubMed: 14665974) »
  • Lan R  et al. Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists. J Med Chem 42:769-76 (1999). Read more (PubMed: 10052983) »
  • Gatley SJ  et al. Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors. Life Sci 61:PL 191-7 (1997). Read more (PubMed: 9335234) »

See all 15 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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