• Product nameAnti-AMACR antibody
    See all AMACR primary antibodies
  • Description
    Rabbit polyclonal to AMACR
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (Human)

  • Positive control
    • Prostate carcinoma.



Our Abpromise guarantee covers the use of ab12498 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesIHC-P: 1/25 - 1/50. Perform heat mediated antigen retrieval with 10 mM citrate buffer, pH 6.0 before commencing with IHC staining protocol. We suggest an incubation period of 30 minutes at room temperature.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionRacemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.
    • PathwayLipid metabolism; bile acid biosynthesis.
      Lipid metabolism; fatty acid metabolism.
    • Involvement in diseaseDefects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) [MIM:614307]. AMACRD results in elevated plasma concentrations of pristanic acid C27-bile-acid intermediates. It can be associated with polyneuropathy, retinitis pigmentosa, epilepsy.
      Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4) [MIM:214950]; also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.
    • Sequence similaritiesBelongs to the CaiB/BaiF CoA-transferase family.
    • Cellular localizationPeroxisome. Mitochondrion.
    • Information by UniProt
    • Database links
    • Alternative names
      • 2 arylpropionyl CoA epimerase antibody
      • 2 methylacyl CoA racemase antibody
      • 2-methylacyl-CoA racemase antibody
      • Alpha methylacyl CoA racemase antibody
      • Alpha methylacyl Coenzyme A racemase antibody
      • Alpha methylacyl-CoA racemase deficiency, included antibody
      • Alpha-methylacyl-CoA racemase antibody
      • Amacr antibody
      • AMACR deficiency, included antibody
      • AMACR_HUMAN antibody
      • CBAS4 antibody
      • Da1-8 antibody
      • EC antibody
      • Macr1 antibody
      • Methylacyl CoA racemase alpha antibody
      • RACE antibody
      • RM antibody
      see all

    Anti-AMACR antibody images

    • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human prostate carcinoma tissue, staining AMACR with ab12498. Staining was detected using DAB.

    References for Anti-AMACR antibody (ab12498)

    ab12498 has not yet been referenced specifically in any publications.

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    Thank you for contacting us.

    All of the antibodies you have chosen are appropriate for the experiments you are hoping to perform. All of the antibodies have been raised against the human protein but the cross reactivity with the mouse protein...

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    Thank you for your enquiry. Rabbit polyclonal to AMACR (ab12498) is suspended in PBS, with 0.05% sodium azide and BSA. The concentration is 100 ug/ml. I hope this information helps, please do not hesitate to contact us if you need any more advice...

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    Thank you for your enquiry. To address your questions: Please excuse my ignorance but according to the literature it seems that P504S and AMACR are interchangeable and synonyms of one another. From the details that I have I can tell you that this an...

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    Thank you for your email. The immunogen used is a recombinant protein encoding full length P504S. If you have any further questions, please contact us again.

    The immunogen used is a recombinant protein encoding full length P504S. If you have any further questions, please contact us again.