Anti-AMACR antibody [Q17-L] - N-terminal (ab190505)

Overview

  • Product name
    Anti-AMACR antibody [Q17-L] - N-terminal
    See all AMACR primary antibodies
  • Description
    Rabbit monoclonal [Q17-L] to AMACR - N-terminal
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human AMACR (N terminal). The exact sequence is proprietary.
    Database link: Q9UHK6

  • Epitope
    Antibody recognizes the epitope located between Leu367 - Ser381
  • Positive control
    • Human papillary renal cell carcinoma and prostate adenocarcinoma tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab190505 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/200.

Target

  • Function
    Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.
  • Pathway
    Lipid metabolism; bile acid biosynthesis.
    Lipid metabolism; fatty acid metabolism.
  • Involvement in disease
    Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) [MIM:614307]. AMACRD results in elevated plasma concentrations of pristanic acid C27-bile-acid intermediates. It can be associated with polyneuropathy, retinitis pigmentosa, epilepsy.
    Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4) [MIM:214950]; also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.
  • Sequence similarities
    Belongs to the CaiB/BaiF CoA-transferase family.
  • Cellular localization
    Peroxisome. Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2 arylpropionyl CoA epimerase antibody
    • 2 methylacyl CoA racemase antibody
    • 2-methylacyl-CoA racemase antibody
    • Alpha methylacyl CoA racemase antibody
    • Alpha methylacyl Coenzyme A racemase antibody
    • Alpha methylacyl-CoA racemase deficiency, included antibody
    • Alpha-methylacyl-CoA racemase antibody
    • Amacr antibody
    • AMACR deficiency, included antibody
    • AMACR_HUMAN antibody
    • CBAS4 antibody
    • Da1-8 antibody
    • EC 5.1.99.4 antibody
    • Macr1 antibody
    • Methylacyl CoA racemase alpha antibody
    • RACE antibody
    • RM antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human prostate adenocarcinoma tissue labeling AMACR with ab190505 at 1/100 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human papillary renal cell carcinoma tissue labeling AMACR with ab190505 at 1/100 dilution.

References

ab190505 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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