Overview

  • Product name
    Ambenonium chloride
  • Description
    Potent, selective, reversible acetylcholinesterase (AChE) inhibitor
  • Alternative names
    • Ambestigmin chloride
    • Misuran
    • Mytelase
    • N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenzenemethaminium) dichloride
  • Biological description

    Extremely potent, selective and rapidly reversible acetylcholinesterase (AChE) inhibitor (IC50 values are 0.0007 and 7 μM at AChE and BChE respectively). Used in the management of myasthenia gravis.

  • Purity
    > 98%

Properties

  • Chemical name
    N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethylbenzenemethanaminium] dichloride
  • Molecular weight
    608.47
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C28H42Cl4N4O2
  • CAS Number
    115-79-7
  • Storage instructions
    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Komloova M  et al. Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment. Bioorg Med Chem Lett 21:2505-9 (2011). Read more (PubMed: 21397501) »
  • Bolognesi ML  et al. Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors. Farmaco 58:917-28 (2003). Read more (PubMed: 13679187) »
  • Hodge AS  et al. Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol Pharmacol 41:937-42 (1992). Read more (PubMed: 1588924) »
  • Papp M Fine structural analysis of the localization of acetylcholinesterase accessible to intraventricular ambenonium chloride in rabbit brain. Neuroscience 4:825-36 (1979). Read more (PubMed: 481753) »

See 0 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab145994.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

Sign up