Anti-AMG antibody (ab153915)
Key features and details
- Rabbit polyclonal to AMG
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-AMG antibody -
Description
Rabbit polyclonal to AMG -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Monkey -
Immunogen
Recombinant fragment corresponding to Human AMG aa 1-191.
Database link: Q99217 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab153915 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 22 kDa.
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IHC-P | (2) |
Use at an assay dependent concentration. PubMed: 29089903
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 22 kDa. |
IHC-P
Use at an assay dependent concentration. PubMed: 29089903 |
Target
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Function
Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. -
Involvement in disease
Defects in AMELX are the cause of amelogenesis imperfecta hypoplastic type 1 (AIH1) [MIM:301200]. AIH1 is a X-linked defect of dental enamel formation. Teeth have only a thin layer of enamel with normal hardness. The thinness of the enamel makes the teeth appear small. -
Sequence similarities
Belongs to the amelogenin family. -
Developmental stage
Transiently but abundantly expressed by ameloblasts during tooth development. Amelogenin is the predominant protein in developing dental enamel. -
Cellular localization
Secreted > extracellular space > extracellular matrix. - Information by UniProt
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Database links
- Entrez Gene: 265 Human
- Entrez Gene: 11704 Mouse
- Omim: 300391 Human
- SwissProt: Q99217 Human
- SwissProt: P63277 Mouse
- Unigene: 654436 Human
- Unigene: 391342 Mouse
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Alternative names
- AI1E antibody
- AIH1 antibody
- ALGN antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (9)
ab153915 has been referenced in 9 publications.
- Bazina F et al. Partial epithelial-mesenchymal transition during enamel development. Clin Exp Dent Res 8:513-518 (2022). PubMed: 35182458
- Suzuki A et al. Crucial Roles of microRNA-16-5p and microRNA-27b-3p in Ameloblast Differentiation Through Regulation of Genes Associated With Amelogenesis Imperfecta. Front Genet 13:788259 (2022). PubMed: 35401675
- Duncan HF et al. The Critical Role of MMP13 in Regulating Tooth Development and Reactionary Dentinogenesis Repair Through the Wnt Signaling Pathway. Front Cell Dev Biol 10:883266 (2022). PubMed: 35531096
- Ma Y et al. Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root development. Development 148:N/A (2021). PubMed: 33323370
- Jing J et al. Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis. Elife 10:N/A (2021). PubMed: 33480845
- Huang W et al. PER2-mediated ameloblast differentiation via PPAR?/AKT1/ß-catenin axis. Int J Oral Sci 13:16 (2021). PubMed: 34011974
- Aryal YP et al. An endoplasmic reticulum stress regulator, Tmbim6, modulates secretory stage of mice molar. J Cell Physiol N/A:N/A (2019). PubMed: 30963569
- Pandya M et al. Intravesicular Phosphatase PHOSPHO1 Function in Enamel Mineralization and Prism Formation. Front Physiol 8:805 (2017). IHC-P ; Mouse . PubMed: 29089903
- Cantù C et al. A cytoplasmic role of Wnt/ß-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation. Sci Signal 10:N/A (2017). PubMed: 28174279