Overview

  • Product nameAnti-AMELX antibody
    See all AMELX primary antibodies
  • Description
    Rabbit polyclonal to AMELX
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Mouse, Rat
  • Immunogen

    A synthetic peptide corresponding to N-terminal residues of mouse AMELX.

Properties

Applications

Our Abpromise guarantee covers the use of ab54507 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 22 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.

Target

  • FunctionPlays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.
  • Involvement in diseaseDefects in AMELX are the cause of amelogenesis imperfecta hypoplastic type 1 (AIH1) [MIM:301200]. AIH1 is a X-linked defect of dental enamel formation. Teeth have only a thin layer of enamel with normal hardness. The thinness of the enamel makes the teeth appear small.
  • Sequence similaritiesBelongs to the amelogenin family.
  • Developmental stageTransiently but abundantly expressed by ameloblasts during tooth development. Amelogenin is the predominant protein in developing dental enamel.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • AI1E antibody
    • AIH1 antibody
    • ALGN antibody
    • Amel antibody
    • Amelogenesis imperfecta 1 antibody
    • Amelogenin (amelogenesis imperfecta 1, X linked) antibody
    • Amelogenin (X chromosome) antibody
    • Amelogenin (X chromosome, amelogenesis imperfecta 1) antibody
    • Amelogenin antibody
    • Amelogenin X isoform antibody
    • Amelogenin, X linked antibody
    • AMELX antibody
    • AMELX_HUMAN antibody
    • Amg antibody
    • AMGL antibody
    • AMGX antibody
    • OTTHUMP00000022906 antibody
    • OTTHUMP00000022907 antibody
    • X isoform antibody
    see all

References for Anti-AMELX antibody (ab54507)

This product has been referenced in:
  • Mazumder P  et al. Amelogenin-Ameloblastin Spatial Interaction around Maturing Enamel Rods. J Dent Res 95:1042-8 (2016). Read more (PubMed: 27146703) »
  • Lacruz RS  et al. Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling. J Cell Physiol 227:2264-75 (2012). Read more (PubMed: 21809343) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"