AMG 9810, TRPV1 receptor antagonist (ab145874)

Overview

  • Product name
    AMG 9810, TRPV1 receptor antagonist
  • Description
    Potent, selective, competitive vanilloid TRPV1 receptor antagonist
  • Biological description
    Potent, selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). Inhibits capsaicin-, proton-, heat- and endogenous ligand-induced activation of human and rat recombinant TRPV1 receptors. Active in vitro and in vivo.

    See similar compounds
  • Purity
    > 99%

Properties

  • Chemical name
    (2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide
  • Molecular weight
    337.42
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C21H23NO3
  • CAS Number
    545395-94-6
  • PubChem identifier
    680502
  • Storage instructions
    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC(C)(C)C1=CC=C(C=C1)/C=C/C(=O)NC2=CC3=C(C=C2)OCCO3
  • Source

    Synthetic

References

This product has been referenced in:
  • Henrich M & Buckler KJ Acid-evoked Ca2+ signalling in rat sensory neurones: effects of anoxia and aglycaemia. Pflugers Arch 459:159-81 (2009). Read more (PubMed: 19806360) »
  • Szallasi A  et al. The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov 6:357-72 (2007). Read more (PubMed: 17464295) »
  • Gavva NR  et al. AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther 313:474-84 (2005). Read more (PubMed: 15615864) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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