Biological descriptionEpithelial sodium channel (eNaC) blocker. At higher concentrations, blocks the Na+/H+ exchange pathway. Also blocks transient reception potential cation (TRPC6 and TRPP3) channels.
Chemical nameN-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 10 mM (with heating) and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Frelin C et al. Amiloride and its analogs as tools to inhibit Na+ transport via the Na+ channel, the Na+/H+ antiport and the Na+/Ca2+ exchanger. Biochimie70:1285-90 (1988).
Read more (PubMed: 2852509) »