Anti-Amino-terminal enhancer of split antibody (ab118280)

Overview

  • Product nameAnti-Amino-terminal enhancer of split antibody
    See all Amino-terminal enhancer of split primary antibodies
  • Description
    Goat polyclonal to Amino-terminal enhancer of split
  • Specificityab118280 is expected to recognize all reported isoforms (NP_945320.1; NP_001121.2; NP_945321.1).
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide:

    SHLPQQLKFTTSD

    by a Cysteine residue linker, corresponding to N terminal amino acids 12-24 of Human Amino-terminal enhancer of split (NP_945320.1; NP_001121.2; NP_945321.1).

  • Positive control
    • Human Brain (Cerebellum and Cerebral Cortex) lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab118280 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 21 kDa).

Target

  • FunctionTranscriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.
  • Tissue specificityFound predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.
  • Sequence similaritiesBelongs to the WD repeat Groucho/TLE family.
  • DomainLacks the C-terminal WD repeats.
  • Post-translational
    modifications
    Ubiquitinated by XIAP/BIRC4.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Aes 1 antibody
    • Aes 2 antibody
    • aes antibody
    • AES_HUMAN antibody
    • Aes1 antibody
    • Aes2 antibody
    • Amino enhancer of split antibody
    • Amino terminal enhancer of split antibody
    • Amino-terminal enhancer of split antibody
    • Esp 1 antibody
    • Esp1 antibody
    • Gp130 associated protein GAM antibody
    • Gp130-associated protein GAM antibody
    • GRG 5 antibody
    • GRG antibody
    • GRG protein antibody
    • Grg-5 antibody
    • GRG5 antibody
    • Groucho-related protein 5 antibody
    • Protein ESP 1 antibody
    • Protein ESP1 antibody
    • Protein GRG antibody
    • TLE 5 antibody
    • TLE5 antibody
    see all

Anti-Amino-terminal enhancer of split antibody images

  • Anti-Amino-terminal enhancer of split antibody (ab118280) at 0.3 µg/ml + Human Cerebral Cortex lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 21 kDa
    Observed band size : 30 kDa (why is the actual band size different from the predicted?)


    Exposure time : 1 hour

References for Anti-Amino-terminal enhancer of split antibody (ab118280)

ab118280 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"