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Rabbit polyclonal to Aminoacylase 1
Predicted to work with:
Mouse, Rat, Cow, Pig
Recombinant protein fragment containing a sequence corresponding to a region within amino acids 89 and 336 of Human Aminoacylase 1 (NP_000657).
293T, A431, HeLa, HepG2, MOLT4, H1299 and Raji cell lysates
ICC/IF: A431 cell
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
Concentration information loading...
Immunogen affinity purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/3000. Predicted molecular weight: 46 kDa.
1/100 - 1/200.
Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).
Expression is highest in kidney, strong in brain and weaker in placenta and spleen.
Involvement in disease
Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D) [MIM:609924]. ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids.
Belongs to the peptidase M20A family.
Information by UniProt
ACY 1 antibody
Western blot - Aminoacylase 1 antibody (ab96098)
Anti-Aminoacylase 1 antibody (ab96098) at 1/1000 dilution + H1299 whole cell lysate at 30 µg
Predicted band size: 46 kDa 10% SDS PAGE
Immunocytochemistry/ Immunofluorescence - Aminoacylase 1 antibody (ab96098)
Immunofluorescence analysis of Aminoacylase 1 in paraformaldehyde fixed A431, using ab96098 at a 1/200 dilution. Lower image merged with DNA probe.
has not yet been referenced specifically in any publications.
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