Overview

  • Product nameAnti-AMN antibody
    See all AMN primary antibodies
  • Description
    Rabbit polyclonal to AMN
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Guinea pig, Cow, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 35-84 (NWSQNRTPCA GGAVEFPADK MVSVLVQEGH AVSDMLLPLD GELVLASGAG) of Human AMN (NP_112205).

  • Positive control
    • Human fetal liver lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab105806 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 46 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionNecessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm.
  • Tissue specificityLong isoforms are highly expressed in small intestine, colon and kidney (renal proximal tubule epithelial cells). Shorter isoforms are detected at lower levels in testis, thymus and peripheral blood leukocytes.
  • Involvement in diseaseDefects in AMN are a cause of recessive hereditary megaloblastic anemia 1 (RH-MGA1) [MIM:261100]; also known as MGA1 Norwegian type or Imerslund-Grasbeck syndrome (I-GS). RH-MGA1 is due to selective malabsorption of vitamin B12. Defects in vitamin B12 absorption lead to impaired function of thymidine synthase. As a consequence DNA synthesis is interrupted. Rapidly dividing cells involved in erythropoiesis are particularly affected.
  • Sequence similaritiesContains 1 VWFC domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5033428N14Rik antibody
    • amn antibody
    • Amnion associated transmembrane protein antibody
    • Amnionless antibody
    • Amnionless homolog antibody
    • AMNLS_HUMAN antibody
    • AV002116 antibody
    • PRO1028 antibody
    • Protein amnionless antibody
    • Type I transmembrane protein antibody
    • UNQ513/PRO1028 antibody
    • Visceral endoderm specific type 1 transmembrane protein antibody
    see all

Anti-AMN antibody images

  • Anti-AMN antibody (ab105806) at 1 µg/ml + Human fetal liver lysate at 10 µg

    Predicted band size : 46 kDa

References for Anti-AMN antibody (ab105806)

ab105806 has not yet been referenced specifically in any publications.

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