Overview

  • Product name
  • Description
    Rabbit polyclonal to AMPD3
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to amino acids 541-776 of Human AMPD3 (BC126118).

  • Positive control
    • Human fetal kidney lysate; Human fetal skeletal muscle tissue.

Properties

  • Form
    Lyophilised:Reconstitute in 200ul sterile water
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 98% PBS, 1% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab118230 is purified by a protein affinity column.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab118230 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/2000. Detects a band of approximately 89 kDa (predicted molecular weight: 89 kDa).
IHC-P 1/100 - 1/500.

Target

  • Function
    AMP deaminase plays a critical role in energy metabolism.
  • Tissue specificity
    Three isoforms are present in mammals: AMP deaminase 1 is the predominant form in skeletal muscle; AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; AMP deaminase 3 is found in erythrocytes.
  • Pathway
    Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.
  • Involvement in disease
    Defects in AMPD3 are the cause of adenosine monophosphate deaminase deficiency erythrocyte type (AMPDDE) [MIM:612874]; also known as erythrocyte AMP deaminase deficiency. AMPDDE is a metabolic disorder due to lack of activity of the erythrocyte isoform of AMP deaminase. It is a clinically asymptomatic condition characterized by a 50% increase in steady-state levels of ATP in affected cells. Individuals with complete deficiency of erythrocyte AMP deaminase are healthy and have no hematologic disorders.
  • Sequence similarities
    Belongs to the adenosine and AMP deaminases family.
  • Information by UniProt
  • Database links
  • Alternative names
    • Adenosine monophosphate deaminase (isoform E) antibody
    • Adenosine monophosphate deaminase 3 antibody
    • AMP aminohydrolase antibody
    • AMP deaminase 3 antibody
    • AMP deaminase isoform E antibody
    • Ampd3 antibody
    • AMPD3_HUMAN antibody
    • Erythrocyte AMP deaminase antibody
    • Erythrocyte specific AMP deaminase antibody
    • Erythrocyte specific protein antibody
    • Erythrocyte type AMP deaminase antibody
    • Erythroid Marker antibody
    • Myoadenylate deaminase antibody
    • OTTHUMP00000230743 antibody
    • OTTHUMP00000230746 antibody
    • OTTHUMP00000230747 antibody
    • OTTHUMP00000230748 antibody
    • OTTHUMP00000230749 antibody
    see all

Images

  • Anti-AMPD3 antibody (ab118230) at 1/1000 dilution + Human fetal kidney lysate

    Predicted band size : 89 kDa
  • ab118230 at 1/100 dilution staining AMPD3 in Formalin-fixed, Paraffin-embedded Human fetal skeletal muscle tissue by Immunohistochemistry.Note cytoplasmic staining.

References

ab118230 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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